The National Institutes of Health (NIH) is inviting applications for this Research Project – Cooperative Agreements. This FOA is one of three issued to create a new program called "Molecular Phenotypes of Null Alleles in Cells (MorPhiC)". The long-term goal of MorPhiC is to develop a consistent catalog of molecular and cellular phenotypes for null alleles for every human gene, using in vitro multicellular systems. The catalog will be made available for broad use by the biomedical community. The program will start with a Phase 1 to optimize available methods to create null alleles and measure their phenotypic effects in a target subset of 1000 protein coding genes across the program. Phase 1 will also assess the scale limitations of such methods, develop common data formats, establish “use cases” for this catalog, and inform whether and how a potential second phase will be implemented. This specific FOA seeks applications for MorPhiC Data Analysis and Validation Centers. These Centers will develop computational models and data analysis and visualization methods to evaluate and help ensure the utility of the MorPhiC data. Separate FOAs will be issued for the two other components of MorPhiC: Data Production Research and Development Centers and a Data Resource and Administrative Coordination Center to receive, annotate, and present data for consortium and public use and to be the administrative coordinating center for the MorPhiC consortium.
Eligibility
- Higher Education Institutions both public and private
- Nonprofits Other Than Institutions of Higher Education
- For-Profit Organizations(small business)
- Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply
- Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.
- Foreign components, as defined in the NIH Grants Policy Statement, are allowed to apply
- Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) is invited to work with his/her organization to develop an application for support.
- Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
Application budgets need to reflect the actual needs of the proposed project but should not exceed $300K direct cost per year. Letter of Intent is 30 days prior to the application due date. Application Due Date is November 1, 2021.
Funder: National Institute of Health (NIH)
URL: https://grants.nih.gov/grants/guide/rfa-files/RFA-HG-21-030.html
Deadline: Letters of intent by October 1, 2021
